Tailoring of PEGylated bilosomes for promoting the transdermal delivery of olmesartan medoxomil: in-vitro characterization, ex-vivo permeation and in-vivo assessment

INTRODUCTION: The intention of this work was to load olmesartan medoxomil (OLM), a sparsely water soluble antihypertensive bioactive with low oral bioavailability (26%), into PEGylated bilosomes (PBs) for augmenting its transdermal delivery. PBs contain PEGylated single chain edge activator besides...

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Bibliographic Details
Published in:Int J Nanomedicine
Main Authors: Albash, Rofida, El-Nabarawi, Mohamed A, Refai, Hanan, Abdelbary, Aly A
Format: Artigo
Language:Inglês
Published: Dove 2019
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6699521/
https://ncbi.nlm.nih.gov/pubmed/31616143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S213613
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