Fabrication of novel elastosomes for boosting the transdermal delivery of diacerein: statistical optimization, ex-vivo permeation, in-vivo skin deposition and pharmacokinetic assessment compared to oral formulation

Diacerein (DCN) is a hydrophobic osteoarthritis (OA) drug with short half-life and low oral bioavailability. Furthermore, DCN oral administration is associated with diarrhea which represents obstacle against its oral use. Hence, this article aimed at developing elastosomes (edge activator (EA)-based...

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Détails bibliographiques
Publié dans:Drug Deliv
Auteurs principaux: Aziz, Diana E., Abdelbary, Aly A., Elassasy, Abdelhalim I.
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6058680/
https://ncbi.nlm.nih.gov/pubmed/29557244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10717544.2018.1451572
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