Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)

[Image: see text] In order to study the role of S1PRs in inflammatory skin disease, S1PR modulators are dosed orally and topically in animal models of disease. The topical application of S1PR modulators in these models may, however, lead to systemic drug concentrations, which can complicate interpre...

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Publicat a:ACS Med Chem Lett
Autors principals: Bell, Mark, Foley, David, Naylor, Claire, Wood, Gavin, Robinson, Colin, Riley, Jennifer, Epemolu, Ola, Ellis, Lucy, Scullion, Paul, Shishikura, Yoko, Osuna-Cabello, Maria, Ferguson, Liam, Pinto, Erika, Fletcher, Daniel, Katz, Elad, McLean, W. H. Irwin, Wyatt, Paul, Read, Kevin D, Woodland, Andrew
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421539/
https://ncbi.nlm.nih.gov/pubmed/30891137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00616
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