Discovery of Soft-Drug Topical Tool Modulators of Sphingosine-1-phosphate Receptor 1 (S1PR1)

[Image: see text] In order to study the role of S1PRs in inflammatory skin disease, S1PR modulators are dosed orally and topically in animal models of disease. The topical application of S1PR modulators in these models may, however, lead to systemic drug concentrations, which can complicate interpre...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Bell, Mark, Foley, David, Naylor, Claire, Wood, Gavin, Robinson, Colin, Riley, Jennifer, Epemolu, Ola, Ellis, Lucy, Scullion, Paul, Shishikura, Yoko, Osuna-Cabello, Maria, Ferguson, Liam, Pinto, Erika, Fletcher, Daniel, Katz, Elad, McLean, W. H. Irwin, Wyatt, Paul, Read, Kevin D, Woodland, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421539/
https://ncbi.nlm.nih.gov/pubmed/30891137
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.8b00616
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