Discovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1

The oral S1PR1 agonist ponesimod demonstrated substantial efficacy in a phase II clinical trial of psoriasis. Unfortunately, systemic side effects were observed, which included lymphopenia and transient bradycardia. We sought to develop a topical soft-drug S1PR1 agonist with an improved therapeutic...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem Lett
Main Authors: Bell, Mark, Foley, David, Naylor, Claire, Robinson, Colin, Riley, Jennifer, Epemolu, Ola, Scullion, Paul, Shishikura, Yoko, Katz, Elad, McLean, W.H. Irwin, Wyatt, Paul, Read, Kevin D., Woodland, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science Ltd 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6185871/
https://ncbi.nlm.nih.gov/pubmed/30143424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2018.07.044
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