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Force generation via β-cardiac myosin, titin, and α-actinin drives cardiac sarcomere assembly from cell-matrix adhesions
Truncating mutations in the sarcomere protein titin cause dilated cardiomyopathy due to sarcomere insufficiency. However, it remains mechanistically unclear how these mutations decrease sarcomere content in cardiomyocytes. Utilizing human induced pluripotent stem cell derived cardiomyocytes, CRISPR/...
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| Опубликовано в: : | Dev Cell |
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| Главные авторы: | , , , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6421364/ https://ncbi.nlm.nih.gov/pubmed/29316444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.12.012 |
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