Force generation via β-cardiac myosin, titin, and α-actinin drives cardiac sarcomere assembly from cell-matrix adhesions

Truncating mutations in the sarcomere protein titin cause dilated cardiomyopathy due to sarcomere insufficiency. However, it remains mechanistically unclear how these mutations decrease sarcomere content in cardiomyocytes. Utilizing human induced pluripotent stem cell derived cardiomyocytes, CRISPR/...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Chopra, Anant, Kutys, Matthew L., Zhang, Kehan, Polacheck, William J., Sheng, Calvin C., Luu, Rebeccah J., Eyckmans, Jeroen, Hinson, J. Travis, Seidman, Jonathan G., Seidman, Christine E., Chen, Christopher S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6421364/
https://ncbi.nlm.nih.gov/pubmed/29316444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2017.12.012
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados