Expression of PD-1 by T cells in malignant glioma patients reflects exhaustion and activation

PURPOSE: Glioblastoma (GBM) is the most common primary malignant tumor in the central nervous system. Our recent pre-clinical work has suggested that PD-1/PD-L1 plays an important immunoregulatory role to limit effective anti-tumor T cell responses induced by active immunotherapy. However, little is...

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Vydáno v:Clin Cancer Res
Hlavní autoři: Davidson, Tom B., Lee, Alexander, Hsu, Melody, Sedighim, Shaina, Orpilla, Joey, Treger, Janet, Mastall, Max, Roesch, Saskia, Rapp, Carmen, Galvez, Mildred, Mochizuki, Aaron, Antonios, Joseph, Garcia, Alejandro, Kotecha, Nikesh, Bayless, Nicholas, Nathanson, David, Wang, Anthony, Everson, Richard, Yong, William H., Cloughesy, Timothy F., Liau, Linda M., Herold-Mende, Christel, Prins, Robert M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420851/
https://ncbi.nlm.nih.gov/pubmed/30498094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-18-1176
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