Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma

BACKGROUND. Adaptive immune resistance in the tumor microenvironment appears to attenuate the immunotherapeutic targeting of glioblastoma (GBM). In this study, we identified a tumor-infiltrating myeloid cell (TIM) population that expands in response to dendritic cell (DC) vaccine treatment. The aim...

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Enregistré dans:
Détails bibliographiques
Publié dans:Neuro Oncol
Auteurs principaux: Antonios, Joseph P., Soto, Horacio, Everson, Richard G., Moughon, Diana, Orpilla, Joey R., Shin, Namjo P., Sedighim, Shaina, Treger, Janet, Odesa, Sylvia, Tucker, Alexander, Yong, William H., Li, Gang, Cloughesy, Timothy F., Liau, Linda M., Prins, Robert M.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Basic and Translational Investigation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464463/
https://ncbi.nlm.nih.gov/pubmed/28115578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now287
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