Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma

BACKGROUND. Adaptive immune resistance in the tumor microenvironment appears to attenuate the immunotherapeutic targeting of glioblastoma (GBM). In this study, we identified a tumor-infiltrating myeloid cell (TIM) population that expands in response to dendritic cell (DC) vaccine treatment. The aim...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Antonios, Joseph P., Soto, Horacio, Everson, Richard G., Moughon, Diana, Orpilla, Joey R., Shin, Namjo P., Sedighim, Shaina, Treger, Janet, Odesa, Sylvia, Tucker, Alexander, Yong, William H., Li, Gang, Cloughesy, Timothy F., Liau, Linda M., Prins, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
Assuntos:
Basic and Translational Investigation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464463/
https://ncbi.nlm.nih.gov/pubmed/28115578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now287
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