Immunosuppressive tumor-infiltrating myeloid cells mediate adaptive immune resistance via a PD-1/PD-L1 mechanism in glioblastoma

BACKGROUND. Adaptive immune resistance in the tumor microenvironment appears to attenuate the immunotherapeutic targeting of glioblastoma (GBM). In this study, we identified a tumor-infiltrating myeloid cell (TIM) population that expands in response to dendritic cell (DC) vaccine treatment. The aim...

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Detalles Bibliográficos
Publicado en:Neuro Oncol
Main Authors: Antonios, Joseph P., Soto, Horacio, Everson, Richard G., Moughon, Diana, Orpilla, Joey R., Shin, Namjo P., Sedighim, Shaina, Treger, Janet, Odesa, Sylvia, Tucker, Alexander, Yong, William H., Li, Gang, Cloughesy, Timothy F., Liau, Linda M., Prins, Robert M.
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2017
Assuntos:
Basic and Translational Investigation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5464463/
https://ncbi.nlm.nih.gov/pubmed/28115578
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/now287
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