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Scaling in vitro activity of CYP3A7 suggests human fetal livers do not clear retinoic acid entering from maternal circulation

All-trans-retinoic acid (atRA), the active metabolite of vitamin A, is a critical signaling molecule during embryonic and fetal development and is necessary for maternal health. Fetal exposure to endogenous atRA is tightly regulated during gestation in a tissue specific manner and maternal exposure...

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Библиографические подробности
Опубликовано в: :Sci Rep
Главные авторы: Topletz, Ariel R., Zhong, Guo, Isoherranen, Nina
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420499/
https://ncbi.nlm.nih.gov/pubmed/30874620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40995-8
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