Early correction of NMDAR function improves autistic-like social behaviors in adult Shank2(−/−) mice

BACKGROUND: Autism spectrum disorders (ASD) involve neurodevelopmental dysregulations that lead to visible symptoms at early stages of life. Many ASD-related mechanisms suggested by animal studies are supported by demonstrated improvement in autistic-like phenotypes in adult animals following experi...

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Publicado no:Biol Psychiatry
Main Authors: Chung, Changuk, Ha, Seungmin, Kang, Hyojin, Lee, Jiseok, Um, Seung Min, Yan, Haidun, Yoo, Ye-Eun, Yoo, Taesun, Jung, Hwajin, Lee, Dongwon, Lee, Eunee, Lee, Seungjoon, Kim, Jihye, Kim, Ryunhee, Kwon, Yonghan, Kim, Woohyun, Kim, Hyosang, Duffney, Lara, Kim, Doyoun, Mah, Won, Won, Hyejung, Mo, Seojung, Kim, Jin Yong, Lim, Chae-Seok, Kaang, Bong-Kiun, Boeckers, Tobias M., Chung, Yeonseung, Kim, Hyun, Jiang, Yong-Hui, Kim, Eunjoon
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420362/
https://ncbi.nlm.nih.gov/pubmed/30466882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biopsych.2018.09.025
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