Memory CD4(+) T cells are generated in the human fetal intestine

The fetus is thought to be protected from exposure to foreign antigens, yet CD45RO(+) T cells reside in the fetal intestine. Here we combined functional assays with mass cytometry, single-cell RNA-sequencing and high-throughput T cell antigen receptor (TCR) sequencing to characterize the CD4(+) T ce...

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Publicado no:Nat Immunol
Main Authors: Li, Na, van Unen, Vincent, Abdelaal, Tamim, Guo, Nannan, Kasatskaya, Sofya A., Ladell, Kristin, McLaren, James E., Egorov, Evgeny S., Izraelson, Mark, Chuva de Sousa Lopes, Susana M., Höllt, Thomas, Britanova, Olga V, Eggermont, Jeroen, de Miranda, Noel F.C.C., Chudakov, Dmitriy M., Price, David A., Lelieveldt, Boudewijn P.F., Koning, Frits
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420108/
https://ncbi.nlm.nih.gov/pubmed/30664737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0294-9
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