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Physicochemical characterization and phase I study of CMAB008, an infliximab biosimilar produced by a different expression system

BACKGROUND: Infliximab (Remicade), a chimeric monoclonal antibody against human TNFα, will inevitably face competition from biosimilar products, because of its effectiveness in autoimmune diseases and rapidly increasing market demand. According to guidelines for biosimilar development, the “biosimil...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: An, Qing, Zheng, Yingxin, Zhao, Yirong, Liu, Tao, Guo, Huaizu, Zhang, Dapeng, Qian, Weizhu, Wang, Hao, Guo, Yajun, Hou, Sheng, Li, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2019
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6420106/
https://ncbi.nlm.nih.gov/pubmed/30880912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S170913
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