Evaluating in vivo efficacy – toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells

BACKGROUND: γ9δ2T cells, which express Vγ9 and Vδ2 chains of the T cell receptor (TCR), mediate cancer immune surveillance by sensing early metabolic changes in malignant leukemic blast and not their healthy hematopoietic stem counterparts via the γ9δ2TCR targeting joined conformational and spatial...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Johanna, Inez, Straetemans, Trudy, Heijhuurs, Sabine, Aarts-Riemens, Tineke, Norell, Håkan, Bongiovanni, Laura, de Bruin, Alain, Sebestyen, Zsolt, Kuball, Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6419469/
https://ncbi.nlm.nih.gov/pubmed/30871629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0558-4
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