Histone demethylase UTX is a therapeutic target for diabetic kidney disease

KEY POINTS: Diabetic kidney disease (DKD) is a major complication of diabetes. We found that UTX (ubiquitously transcribed tetratricopeptide repeat on chromosome X, also known as KDM6A), a histone demethylase, was upregulated in the renal mesangial and tubular cells of diabetic mice and DKD patients...

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Vydáno v:J Physiol
Hlavní autoři: Chen, Hong, Huang, Yixue, Zhu, Xiuqin, Liu, Chong, Yuan, Yangmian, Su, Hua, Zhang, Chun, Liu, Chengyu, Xiong, Mingrui, Qu, Yannan, Yun, Peng, Zheng, Ling, Huang, Kun
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
Renal
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418754/
https://ncbi.nlm.nih.gov/pubmed/30516825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP277367
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