In vivo CRISPR screening unveils histone demethylase UTX as an important epigenetic regulator in lung tumorigenesis

Lung cancer is the leading cause of cancer-related death worldwide. Inactivation of tumor suppressor genes (TSGs) promotes lung cancer malignant progression. Here, we take advantage of the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated somatic gene knockout in a Kra...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Wu, Qibiao, Tian, Yahui, Zhang, Jian, Tong, Xinyuan, Huang, Hsinyi, Li, Shuai, Zhao, Hong, Tang, Ying, Yuan, Chongze, Wang, Kun, Fang, Zhaoyuan, Gao, Lei, Hu, Xin, Li, Fuming, Qin, Zhen, Yao, Shun, Chen, Ting, Chen, Haiquan, Zhang, Gong, Liu, Wanting, Sun, Yihua, Chen, Luonan, Wong, Kwok-Kin, Ge, Kai, Chen, Liang, Ji, Hongbin
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2018
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5924887/
https://ncbi.nlm.nih.gov/pubmed/29632194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716589115
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