ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination

Deubiquitination of NLRP3 has been suggested to contribute to inflammasome activation, but the roles and molecular mechanisms are still unclear. We here demonstrate that ABRO1, a subunit of the BRISC deubiquitinase complex, is necessary for optimal NLRP3‐ASC complex formation, ASC oligomerization, c...

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書目詳細資料
發表在:EMBO J
Main Authors: Ren, Guangming, Zhang, Xuanyi, Xiao, Yang, Zhang, Wen, Wang, Yu, Ma, Wenbing, Wang, Xiaohan, Song, Pan, Lai, Lili, Chen, Hui, Zhan, Yiqun, Zhang, Jianhong, Yu, Miao, Ge, Changhui, Li, Changyan, Yin, Ronghua, Yang, Xiaoming
格式: Artigo
語言:Inglês
出版: John Wiley and Sons Inc. 2019
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Articles
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418445/
https://ncbi.nlm.nih.gov/pubmed/30787184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100376
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