ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination

Deubiquitination of NLRP3 has been suggested to contribute to inflammasome activation, but the roles and molecular mechanisms are still unclear. We here demonstrate that ABRO1, a subunit of the BRISC deubiquitinase complex, is necessary for optimal NLRP3‐ASC complex formation, ASC oligomerization, c...

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Publicado en:EMBO J
Autores principales: Ren, Guangming, Zhang, Xuanyi, Xiao, Yang, Zhang, Wen, Wang, Yu, Ma, Wenbing, Wang, Xiaohan, Song, Pan, Lai, Lili, Chen, Hui, Zhan, Yiqun, Zhang, Jianhong, Yu, Miao, Ge, Changhui, Li, Changyan, Yin, Ronghua, Yang, Xiaoming
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418445/
https://ncbi.nlm.nih.gov/pubmed/30787184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100376
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