ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination

Deubiquitination of NLRP3 has been suggested to contribute to inflammasome activation, but the roles and molecular mechanisms are still unclear. We here demonstrate that ABRO1, a subunit of the BRISC deubiquitinase complex, is necessary for optimal NLRP3‐ASC complex formation, ASC oligomerization, c...

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Dades bibliogràfiques
Publicat a:EMBO J
Autors principals: Ren, Guangming, Zhang, Xuanyi, Xiao, Yang, Zhang, Wen, Wang, Yu, Ma, Wenbing, Wang, Xiaohan, Song, Pan, Lai, Lili, Chen, Hui, Zhan, Yiqun, Zhang, Jianhong, Yu, Miao, Ge, Changhui, Li, Changyan, Yin, Ronghua, Yang, Xiaoming
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418445/
https://ncbi.nlm.nih.gov/pubmed/30787184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100376
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