ABRO1 promotes NLRP3 inflammasome activation through regulation of NLRP3 deubiquitination

Deubiquitination of NLRP3 has been suggested to contribute to inflammasome activation, but the roles and molecular mechanisms are still unclear. We here demonstrate that ABRO1, a subunit of the BRISC deubiquitinase complex, is necessary for optimal NLRP3‐ASC complex formation, ASC oligomerization, c...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Ren, Guangming, Zhang, Xuanyi, Xiao, Yang, Zhang, Wen, Wang, Yu, Ma, Wenbing, Wang, Xiaohan, Song, Pan, Lai, Lili, Chen, Hui, Zhan, Yiqun, Zhang, Jianhong, Yu, Miao, Ge, Changhui, Li, Changyan, Yin, Ronghua, Yang, Xiaoming
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418445/
https://ncbi.nlm.nih.gov/pubmed/30787184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2018100376
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