CHD4 regulates the DNA damage response and RAD51 expression in glioblastoma

Glioblastoma (GBM) is a lethal brain tumour. Despite therapy with surgery, radiation, and alkylating chemotherapy, most people have recurrence within 6 months and die within 2 years. A major reason for recurrence is resistance to DNA damage. Here, we demonstrate that CHD4, an ATPase and member of th...

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Опубликовано в: :Sci Rep
Главные авторы: McKenzie, Lisa D., LeClair, John W., Miller, Kayla N., Strong, Averey D., Chan, Hilda L., Oates, Edward L., Ligon, Keith L., Brennan, Cameron W., Chheda, Milan G.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6418088/
https://ncbi.nlm.nih.gov/pubmed/30872624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40327-w
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