Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity

BACKGROUND: Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformatio...

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Bibliographic Details
Published in:J Biomed Sci
Main Authors: Volarevic, Vladislav, Djokovic, Bojana, Jankovic, Marina Gazdic, Harrell, C. Randall, Fellabaum, Crissy, Djonov, Valentin, Arsenijevic, Nebojsa
Format: Artigo
Language:Inglês
Published: BioMed Central 2019
Subjects:
Review
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417243/
https://ncbi.nlm.nih.gov/pubmed/30866950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-019-0518-9
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