Galectin 3 protects from cisplatin-induced acute kidney injury by promoting TLR-2-dependent activation of IDO1/Kynurenine pathway in renal DCs

Strategies targeting cross-talk between immunosuppressive renal dendritic cells (DCs) and T regulatory cells (Tregs) may be effective in treating cisplatin (CDDP)-induced acute kidney injury (AKI). Galectin 3 (Gal-3), expressed on renal DCs, is known as a crucial regulator of immune response in the...

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Pubblicato in:Theranostics
Autori principali: Volarevic, Vladislav, Markovic, Bojana Simovic, Jankovic, Marina Gazdic, Djokovic, Bojana, Jovicic, Nemanja, Harrell, C. Randall, Fellabaum, Crissy, Djonov, Valentin, Arsenijevic, Nebojsa, Lukic, Miodrag L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ivyspring International Publisher 2019
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6735380/
https://ncbi.nlm.nih.gov/pubmed/31534532
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.33959
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