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Molecular mechanisms of cisplatin-induced nephrotoxicity: a balance on the knife edge between renoprotection and tumor toxicity

BACKGROUND: Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformatio...

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Publicat a:J Biomed Sci
Autors principals: Volarevic, Vladislav, Djokovic, Bojana, Jankovic, Marina Gazdic, Harrell, C. Randall, Fellabaum, Crissy, Djonov, Valentin, Arsenijevic, Nebojsa
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417243/
https://ncbi.nlm.nih.gov/pubmed/30866950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12929-019-0518-9
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