Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment

BACKGROUND: Immunotherapies still fail to benefit colorectal cancer (CRC) patients. Relevant functional assays aimed at studying these failures and the efficacy of cancer immunotherapy in human are scarce. 3D tumor cultures, called tumor organoids or spheroids, represent interesting models to study...

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Veröffentlicht in:J Immunother Cancer
Hauptverfasser: Courau, Tristan, Bonnereau, Julie, Chicoteau, Justine, Bottois, Hugo, Remark, Romain, Assante Miranda, Laura, Toubert, Antoine, Blery, Mathieu, Aparicio, Thomas, Allez, Matthieu, Le Bourhis, Lionel
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417026/
https://ncbi.nlm.nih.gov/pubmed/30871626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0553-9
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