Cocultures of human colorectal tumor spheroids with immune cells reveal the therapeutic potential of MICA/B and NKG2A targeting for cancer treatment

BACKGROUND: Immunotherapies still fail to benefit colorectal cancer (CRC) patients. Relevant functional assays aimed at studying these failures and the efficacy of cancer immunotherapy in human are scarce. 3D tumor cultures, called tumor organoids or spheroids, represent interesting models to study...

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Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Courau, Tristan, Bonnereau, Julie, Chicoteau, Justine, Bottois, Hugo, Remark, Romain, Assante Miranda, Laura, Toubert, Antoine, Blery, Mathieu, Aparicio, Thomas, Allez, Matthieu, Le Bourhis, Lionel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6417026/
https://ncbi.nlm.nih.gov/pubmed/30871626
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40425-019-0553-9
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