The MICA-129Met/Val dimorphism affects plasma membrane expression and shedding of the NKG2D ligand MICA

The MHC class I chain-related molecule A (MICA) is a ligand for the activating natural killer (NK) cell receptor NKG2D. A polymorphism causing a valine to methionine exchange at position 129 affects binding to NKG2D, cytotoxicity, interferon-γ release by NK cells and activation of CD8(+) T cells. It...

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Detalhes bibliográficos
Publicado no:Immunogenetics
Main Authors: Isernhagen, Antje, Schilling, Daniela, Monecke, Sebastian, Shah, Pranali, Elsner, Leslie, Walter, Lutz, Multhoff, Gabriele, Dressel, Ralf
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Berlin Heidelberg 2015
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4728179/
https://ncbi.nlm.nih.gov/pubmed/26585323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00251-015-0884-8
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