Anti-cancer Effects of a Chemically Modified miR-143 on Bladder Cancer by Either Systemic or Intravesical Treatment

We developed a novel chemically modified miR-143 (miR-143#12), and with it we investigated the contribution of miR-143 to the pathogenesis of bladder cancer (BC), in which miR-143 is extremely downregulated. Since miR-143 silenced K-RAS and RAS effector-signaling molecules Erk and Akt, we performed...

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Bibliografiska uppgifter
I publikationen:Mol Ther Methods Clin Dev
Huvudupphovsmän: Yoshikawa, Yuki, Taniguchi, Kohei, Tsujino, Takuya, Heishima, Kazuki, Inamoto, Teruo, Takai, Tomoaki, Minami, Koichiro, Azuma, Haruhito, Miyata, Kanjiro, Hayashi, Kotaro, Kataoka, Kazunori, Akao, Yukihiro
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Gene & Cell Therapy 2019
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416526/
https://ncbi.nlm.nih.gov/pubmed/30911586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtm.2019.02.005
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