Crystal structures of multidrug efflux pump MexB bound with high-molecular-mass compounds

RND-type multidrug efflux pumps have two voluminous multisite drug-binding pockets named the proximal and distal binding pocket. High- and low-molecular-mass drugs bind to these proximal and distal pocket, respectively. Here, we report the crystal structures of MexB of Pseudomonas aeruginosa bound w...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Sakurai, Keisuke, Yamasaki, Seiji, Nakao, Kaori, Nishino, Kunihiko, Yamaguchi, Akihito, Nakashima, Ryosuke
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6416280/
https://ncbi.nlm.nih.gov/pubmed/30867446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40232-2
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