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Multiple entry pathways within the efflux transporter AcrB contribute to multidrug recognition
AcrB is the major multidrug exporter in Escherichia coli. Although several substrate-entrances have been identified, the specificity of these various transport paths remains unclear. Here we present evidence for a substrate channel (channel 3) from the central cavity of the AcrB trimer, which is co...
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| Опубликовано в: : | Nat Commun |
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| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group UK
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5760665/ https://ncbi.nlm.nih.gov/pubmed/29317622 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-02493-1 |
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