Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains

The overexpression of RND-type exporters is one of the main causes of multidrug resistance (MDR) in Gram-negative pathogens. In RND transporters, such as Escherichia coli's main efflux pump AcrB, drug efflux occurs in the porter domain, while protons flow through the transmembrane domain: remot...

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Detalles Bibliográficos
Publicado en:Front Microbiol
Main Authors: Zwama, Martijn, Hayashi, Katsuhiko, Sakurai, Keisuke, Nakashima, Ryosuke, Kitagawa, Kimie, Nishino, Kunihiko, Yamaguchi, Akihito
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Microbiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5661021/
https://ncbi.nlm.nih.gov/pubmed/29118749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.02095
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