Nucleosome DNA unwrapping does not affect prototype foamy virus integration efficiency or site selection

Eukaryotic DNA binding proteins must access genomic DNA that is packaged into chromatin in vivo. During a productive infection, retroviral integrases (IN) must similarly interact with chromatin to integrate the viral cDNA genome. Here we examine the role of nucleosome DNA unwrapping in the retrovira...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Mackler, Randi M., Jones, Nathan D., Gardner, Anne M., Lopez, Miguel A., Howard, Cecil J., Fishel, Richard, Yoder, Kristine E.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2019
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415784/
https://ncbi.nlm.nih.gov/pubmed/30865665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0212764
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