Caveolin-3 KO disrupts t-tubule structure and decreases t-tubular I(Ca) density in mouse ventricular myocytes

Caveolin-3 (Cav-3) is a protein that has been implicated in t-tubule formation and function in cardiac ventricular myocytes. In cardiac hypertrophy and failure, Cav-3 expression decreases, t-tubule structure is disrupted, and excitation-contraction coupling is impaired. However, the extent to which...

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Gepubliceerd in:Am J Physiol Heart Circ Physiol
Hoofdauteurs: Bryant, Simon M., Kong, Cherrie H. T., Watson, Judy J., Gadeberg, Hanne C., Roth, David M., Patel, Hemal H., Cannell, Mark B., James, Andrew F., Orchard, Clive H.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6415741/
https://ncbi.nlm.nih.gov/pubmed/30028203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00209.2018
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