AtrR Is an Essential Determinant of Azole Resistance in Aspergillus fumigatus

Aspergillosis associated with azole-resistant Aspergillus fumigatus has a mortality rate that can approach 90% in certain patient populations. The best-understood avenue for azole resistance involves changes in the cyp51A gene that encodes the target of azole drugs, lanosterol α-14 demethylase. The...

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Bibliografske podrobnosti
izdano v:mBio
Main Authors: Paul, Sanjoy, Stamnes, Mark, Thomas, Grace Heredge, Liu, Hong, Hagiwara, Daisuke, Gomi, Katsuya, Filler, Scott G., Moye-Rowley, W. Scott
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6414702/
https://ncbi.nlm.nih.gov/pubmed/30862750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02563-18
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