A recombinant human IgG1 Fc multimer designed to mimic the active fraction of IVIG in autoimmunity

The antiinflammatory effects of i.v. Ig (IVIG) in the treatment of autoimmune disease are due, in part, to the Fc fragments of Ig aggregates. In order to capitalize on the known antiinflammatory and tolerogenic properties of Ig Fc aggregates, we created a recombinant human IgG1 Fc multimer, GL-2045....

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Zhang, Xiaoyu, Owens, Jane, Olsen, Henrik S., So, Edward, Burch, Erin, McCroskey, Mark C., Li, Xianfeng, Weber, Gregory L., Bennett, Donald, Rybin, Denis, Zhou, Hua, Hao, Haiping, Mérigeon, Emmanuel Y., Block, David S., LaRosa, Gregory, Strome, Scott E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413835/
https://ncbi.nlm.nih.gov/pubmed/30674715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121905
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