A fully recombinant human IgG1 Fc multimer (GL-2045) inhibits complement-mediated cytotoxicity and induces iC3b

GL-2045 is a recombinant human immunoglobulin G1 (IgG1)–based Fc multimer designed to recapitulate the anti-inflammatory activities of intravenous immunoglobulin (IVIG) on the innate and adaptive immune responses. We used functional in vitro studies to determine if GL-2045 could mimic the modulatory...

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Detalhes bibliográficos
Publicado no:Blood Adv
Main Authors: Zhou, Hua, Olsen, Henrik, So, Edward, Mérigeon, Emmanuel, Rybin, Denis, Owens, Jane, LaRosa, Gregory, Block, David S., Strome, Scott E., Zhang, Xiaoyu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2017
Assuntos:
Immunobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5728453/
https://ncbi.nlm.nih.gov/pubmed/29296968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016001917
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