Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity

IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. Sialylated IgG Fc domains have antiinflammatory properties that are attributed to their ability to increase the activation threshold of innate effector ce...

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Enregistré dans:
Détails bibliographiques
Publié dans:J Clin Invest
Auteurs principaux: Quast, Isaak, Keller, Christian W., Maurer, Michael A., Giddens, John P., Tackenberg, Björn, Wang, Lai-Xi, Münz, Christian, Nimmerjahn, Falk, Dalakas, Marinos C., Lünemann, Jan D.
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2015
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4639970/
https://ncbi.nlm.nih.gov/pubmed/26436649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82695
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