Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity

IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. Sialylated IgG Fc domains have antiinflammatory properties that are attributed to their ability to increase the activation threshold of innate effector ce...

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Detalles Bibliográficos
Publicado en:J Clin Invest
Autores principales: Quast, Isaak, Keller, Christian W., Maurer, Michael A., Giddens, John P., Tackenberg, Björn, Wang, Lai-Xi, Münz, Christian, Nimmerjahn, Falk, Dalakas, Marinos C., Lünemann, Jan D.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2015
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4639970/
https://ncbi.nlm.nih.gov/pubmed/26436649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82695
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