Sialylation of IgG Fc domain impairs complement-dependent cytotoxicity

IgG molecules exert both pro- and antiinflammatory effector functions based on the composition of the fragment crystallizable (Fc) domain glycan. Sialylated IgG Fc domains have antiinflammatory properties that are attributed to their ability to increase the activation threshold of innate effector ce...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Quast, Isaak, Keller, Christian W., Maurer, Michael A., Giddens, John P., Tackenberg, Björn, Wang, Lai-Xi, Münz, Christian, Nimmerjahn, Falk, Dalakas, Marinos C., Lünemann, Jan D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4639970/
https://ncbi.nlm.nih.gov/pubmed/26436649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI82695
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