A recombinant human IgG1 Fc multimer designed to mimic the active fraction of IVIG in autoimmunity

The antiinflammatory effects of i.v. Ig (IVIG) in the treatment of autoimmune disease are due, in part, to the Fc fragments of Ig aggregates. In order to capitalize on the known antiinflammatory and tolerogenic properties of Ig Fc aggregates, we created a recombinant human IgG1 Fc multimer, GL-2045....

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:JCI Insight
Egile Nagusiak: Zhang, Xiaoyu, Owens, Jane, Olsen, Henrik S., So, Edward, Burch, Erin, McCroskey, Mark C., Li, Xianfeng, Weber, Gregory L., Bennett, Donald, Rybin, Denis, Zhou, Hua, Hao, Haiping, Mérigeon, Emmanuel Y., Block, David S., LaRosa, Gregory, Strome, Scott E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Clinical Investigation 2019
Gaiak:
Research Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413835/
https://ncbi.nlm.nih.gov/pubmed/30674715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121905
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