A recombinant human IgG1 Fc multimer designed to mimic the active fraction of IVIG in autoimmunity

The antiinflammatory effects of i.v. Ig (IVIG) in the treatment of autoimmune disease are due, in part, to the Fc fragments of Ig aggregates. In order to capitalize on the known antiinflammatory and tolerogenic properties of Ig Fc aggregates, we created a recombinant human IgG1 Fc multimer, GL-2045....

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Bibliografiske detaljer
Udgivet i:JCI Insight
Main Authors: Zhang, Xiaoyu, Owens, Jane, Olsen, Henrik S., So, Edward, Burch, Erin, McCroskey, Mark C., Li, Xianfeng, Weber, Gregory L., Bennett, Donald, Rybin, Denis, Zhou, Hua, Hao, Haiping, Mérigeon, Emmanuel Y., Block, David S., LaRosa, Gregory, Strome, Scott E.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413835/
https://ncbi.nlm.nih.gov/pubmed/30674715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.121905
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