PET/CT monitoring demonstrates a therapeutic response to oxazolidinones in Mycobacterium tuberculosis-infected macaques and humans

Oxazolidinone antibiotics such as linezolid have shown significant therapeutic effects in patients with extensively drug-resistant (XDR) tuberculosis (TB) despite modest effects in rodents and no demonstrable early bactericidal activity in human Phase 2 trials. Here, we show that monotherapy with ei...

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Vydáno v:Sci Transl Med
Hlavní autoři: Coleman, M. Teresa, Chen, Ray Y., Lee, Myungsun, Lin, Philana Ling, Dodd, Lori E., Maiello, Pauline, Via, Laura E., Kim, Youngran, Marriner, Gwendolyn, Dartois, Veronique, Scanga, Charles, Janssen, Christopher, Wang, Jing, Klein, Edwin, Cho, Sang Nae, Barry, Clifton E., Flynn, JoAnne L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413515/
https://ncbi.nlm.nih.gov/pubmed/25473035
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3009500
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