Investigating a chimeric anti-mouse PDGFRα antibody as a radiosensitizer in primary mouse sarcomas

BACKGROUND: Olaratumab (LY3012207/IMC-3G3/Lartruvo™) is a fully human monoclonal antibody specific for platelet-derived growth factor receptor alpha (PDGFRα). Phase Ib/II trial results of olaratumab plus doxorubicin in adult patients with advanced soft tissue sarcoma (STS) supported accelerated FDA...

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Detalles Bibliográficos
Publicado en:EBioMedicine
Autores principales: Song, Erin J., Ashcraft, Kathleen A., Lowery, Caitlin D., Mowery, Yvonne M., Luo, Lixia, Ma, Yan, Campos, Lorraine Da Silva, Cardona, Diana M., Stancato, Louis, Kirsch, David G.
Formato: Artigo
Lenguaje:Inglês
Publicado: Elsevier 2019
Materias:
Research paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6413473/
https://ncbi.nlm.nih.gov/pubmed/30711517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.01.046
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