Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma

Genetically engineered mouse models that employ site-specific recombinase technology are important tools for cancer research but can be costly and time-consuming. The CRISPR-Cas9 system has been adapted to generate autochthonous tumours in mice, but how these tumours compare to tumours generated by...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Huang, Jianguo, Chen, Mark, Whitley, Melodi Javid, Kuo, Hsuan-Cheng, Xu, Eric S., Walens, Andrea, Mowery, Yvonne M., Van Mater, David, Eward, William C., Cardona, Diana M., Luo, Lixia, Ma, Yan, Lopez, Omar M., Nelson, Christopher E., Robinson-Hamm, Jacqueline N., Reddy, Anupama, Dave, Sandeep S., Gersbach, Charles A., Dodd, Rebecca D., Kirsch, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5508130/
https://ncbi.nlm.nih.gov/pubmed/28691711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15999
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