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Regulation of Rep helicase unwinding by an auto-inhibitory subdomain

Helicases are biomolecular motors that unwind nucleic acids, and their regulation is essential for proper maintenance of genomic integrity. Escherichia coli Rep helicase, whose primary role is to help restart stalled replication, serves as a model for Superfamily I helicases. The activity of Rep-lik...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Makurath, Monika A, Whitley, Kevin D, Nguyen, Binh, Lohman, Timothy M, Chemla, Yann R
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412110/
https://ncbi.nlm.nih.gov/pubmed/30690484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkz023
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