Donor-derived cell-free DNA predicts allograft failure and mortality after lung transplantation

BACKGROUND: Allograft failure is common in lung-transplant recipients and leads to poor outcomes including early death. No reliable clinical tools exist to identify patients at high risk for allograft failure. This study tested the use of donor-derived cell-free DNA (%ddcfDNA) as a sensitive marker...

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Pubblicato in:EBioMedicine
Autori principali: Agbor-Enoh, Sean, Wang, Yan, Tunc, Ilker, Jang, Moon Kyoo, Davis, Andrew, De Vlaminck, Iwijn, Luikart, Helen, Shah, Pali D., Timofte, Irina, Brown, Anne W., Marishta, Argit, Bhatti, Kenneth, Gorham, Sasha, Fideli, Ulgen, Wylie, Jennifer, Grimm, David, Goodwin, Natalie, Yang, Yanqin, Patel, Kapil, Zhu, Jun, Iacono, Aldo, Orens, Jonathan B., Nathan, Steven D., Marboe, Charles, Berry, Gerald J., Quake, Stephen R., Khush, Kiran, Valantine, Hannah A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6412014/
https://ncbi.nlm.nih.gov/pubmed/30692045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2018.12.029
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