Monitoring Pharmacologically Induced Immunosuppression by Immune Repertoire Sequencing to Detect Acute Allograft Rejection in Heart Transplant Patients: A Proof-of-Concept Diagnostic Accuracy Study

BACKGROUND: It remains difficult to predict and to measure the efficacy of pharmacological immunosuppression. We hypothesized that measuring the B-cell repertoire would enable assessment of the overall level of immunosuppression after heart transplantation. METHODS AND FINDINGS: In this proof-of-con...

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Publicado en:PLoS Med
Autores principales: Vollmers, Christopher, De Vlaminck, Iwijn, Valantine, Hannah A., Penland, Lolita, Luikart, Helen, Strehl, Calvin, Cohen, Garrett, Khush, Kiran K., Quake, Stephen R.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4605651/
https://ncbi.nlm.nih.gov/pubmed/26466143
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pmed.1001890
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