Single-stranded DNA library preparation uncovers the origin and diversity of ultrashort cell-free DNA in plasma

Circulating cell-free DNA (cfDNA) is emerging as a powerful monitoring tool in cancer, pregnancy and organ transplantation. Nucleosomal DNA, the predominant form of plasma cfDNA, can be adapted for sequencing via ligation of double-stranded DNA (dsDNA) adapters. dsDNA library preparations, however,...

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Udgivet i:Sci Rep
Main Authors: Burnham, Philip, Kim, Min Seong, Agbor-Enoh, Sean, Luikart, Helen, Valantine, Hannah A., Khush, Kiran K., De Vlaminck, Iwijn
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4906518/
https://ncbi.nlm.nih.gov/pubmed/27297799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27859
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