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USP18 and ISG15 coordinately impact on SKP2 and cell cycle progression
USP18 is an isopeptidase that cleaves the ubiquitin-like ISG15 from conjugates and is also an essential negative feedback regulator of type I interferon signaling. We and others reported that USP18 protein is stabilized by ISG15 and targeted for degradation by SKP2 (S-phase kinase associated protein...
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| Publié dans: | Sci Rep |
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| Auteurs principaux: | , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
Nature Publishing Group UK
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6411882/ https://ncbi.nlm.nih.gov/pubmed/30858391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39343-7 |
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