The role of SLX4 and its associated nucleases in DNA interstrand crosslink repair

A key step in the Fanconi anemia pathway of DNA interstrand crosslink (ICL) repair is the ICL unhooking by dual endonucleolytic incisions. SLX4/FANCP is a large scaffold protein that plays a central role in ICL unhooking. It contains multiple domains that interact with many proteins including three...

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Udgivet i:Nucleic Acids Res
Main Authors: Hoogenboom, Wouter S, Boonen, Rick A C M, Knipscheer, Puck
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2019
Fag:
Genome Integrity, Repair and Replication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411836/
https://ncbi.nlm.nih.gov/pubmed/30576517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky1276
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