Pan-cancer association of a centrosome amplification gene expression signature with genomic alterations and clinical outcome

Centrosome amplification (CA) is a common feature of human tumours and a promising target for cancer therapy. However, CA’s pan-cancer prevalence, molecular role in tumourigenesis and therapeutic value in the clinical setting are still largely unexplored. Here, we used a transcriptomic signature (CA...

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Detalles Bibliográficos
Publicado en:PLoS Comput Biol
Main Authors: de Almeida, Bernardo P., Vieira, André F., Paredes, Joana, Bettencourt-Dias, Mónica, Barbosa-Morais, Nuno L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2019
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411098/
https://ncbi.nlm.nih.gov/pubmed/30856170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1006832
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